A Direct Approach to the Synthesis of Famciclovir and Penciclovir |
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| Authors: | Bernadette M Choudary Graham R Geen Peter M Kincey Martin J Parratt J Robert M Dales |
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| Institution: | 1. SmithKline Beecham Pharmaceuticals, New Frontiers Science Park , Third Avenue, Harlow, Essex, CM19 5AW, U. K.;2. SmithKline Beecham Pharmaceuticals , Clarendon Road, Worthing, West Sussex, BN14 8QH, U. K. |
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| Abstract: | Abstract Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1-tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its oral from famciclovir in three isolated steps. |
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