The Synthesis of 5-Substituted-2, 4-dimethoxypyrimidines and Some Related Nucleoside Analogues |
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Authors: | R. F. Whale P. L. Coe R. T. Walker |
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Affiliation: | School of Chemistry, University of Birmingham , PO Box 363, Birmingham, B15 2TT |
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Abstract: | Abstract The reaction of 5-formyl-2,4-dimethoxypyrimidine with active methylene compounds in the Knoevenagel reaction and the subsequent nucleoside formation reactions of some of the products was investigated. A new synthesis of (E)-5-(2-bromovinyl)uracil and an improved synthesis of 5-formyl-2′,3′-isopropylidene uridine are reported. |
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