Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. I: Guanosine Analogues |
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| Authors: | J M Blanco O Caamaño F Fernández G Gómez M I Nieto J Balzarini |
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| Institution: | 1. Departamento de Quimica Orgánica, Facultad de Farmacia , Universidad de Santiago , E-15706, Santiago de Compostela, Spain;2. Departamento de Química Puray Aplicada, E.U.I.T.I. , Universidad de Vigo , Torrecedeira 86, E-36208, Vigo, Spain;3. Rega Institute for Medical Research, Katholieke Universiteit , Leuven, B-3000, Leuven, Belgium |
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| Abstract: | Abstract Six new carbocyclic nucleosides were prepared by constructing a guanine (compounds 6, 8 and 10) or 8-azaguanine (compounds 7, 9 and 11) base on the amino group of (1R, cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2), and their activities against 13 viruses and 3 tumor cell lines were determined. Compounds 9, 10 and 11 showed activity against human immunodeficiency virus type 1 (HIV-1), and compound 11 also against vaccina virus, whereas compounds 6 and 7 showed some inhibition of tumor cell proliferation. |
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