Arylamidation of Purine Nucleosides by 2-Acetylalkoxy- Aminofluorene - an Intramolecular Approach to the Synthesis of Nucleoside - Carcinogen Adducts |
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| Authors: | A Leterme M F Lhomme J Lhomme |
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| Institution: | Chimie Organique Biologique - UA CNRS 351 , Universite des Sciences et Techniques de Lille , Flandres - Artois, 59655, Villeneuve d'Ascq Cedex, France |
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| Abstract: | Abstract Arylamidation of the guanosine ring at position C-8 by the carcinogen N-2acetylalkoxyaminofluorene was achieved using an intramolecular approach. |
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| Keywords: | Fluoropyrimidine 5FU Cancer chemotherapy Thymidylate synthase |
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