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Biologically Active Oligodeoxyribonucleotides - IV: Anti-HIV-1 Activity of Tgggag Having Hydrophobic Substituent at Its 5′-End via Phosphodiester Linkage |
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| Authors: | Hitoshi Hotoda Makoto Koizumi Rika Koga Kenji Momota Toshinori Ohmine Hidehiko Furukawa |
| Institution: | 1. Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo , 140 , Japan;2. Biological Research Laboratories, Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo , 140 , Japan |
| Abstract: | Abstract Hexadeoxyribonucleotides (6-mers) having a 5′-TGGGAG-3′ sequence bearing hydrophobic substituents at their 5′-ends via phosphodiester linkages were prepared and evaluated for anti-HIV-1 activity in vitro. Some of these modified 6-mers showed weak anti-HIV-1 activities and they were less potent than the 6-mer having a DMTr group directly attached at its 5′-terminus. |
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