Synthesis of 5-Mercaptocytosine Nucleosides and Nucleotides |
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| Authors: | V C Solan G L Szekeres E K Ryu H Kung Y K Ho T J Bardos |
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| Institution: | Department of Medicinal Chemistry , School of Pharmacy, State University of New York at Buffalo , Amherst , New York , 14260 |
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| Abstract: | Abstract The synthesis of a series of new nucleosides and nucleotides, including ribo-, 2-deoxyribo- and arabinofuranosides of 5-sulfur-substituted cytosines, is described. The synthetic methods employed involve 5-thiolation of the appropriate cytosine or 5-bromocytosine nucleosides and nucleotides, or alternatively, 4-thiation followed by amination of the corresponding protected 5-(S-benzyl)mercaptouracil nucleosides and subsequent deblocking with sodium and liquid ammonia. |
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