Enzymatic Recognition of Acyclic Universal Base Analogues in Oligonucleotides |
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| Authors: | D. Loakes A Van Aerschotl D. M. Brown F. Hill |
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| Affiliation: | 1. Medical Research Council Laboratory of Molecular Biology , Hills Road Cambridge , CB2 2QH, UK;2. Katholieke Universiteit Leuven Laboratory of Medicinal Chemistry , Rega Institute , Minderbroedersstraat 10, B-3000, Leuven, Belgium |
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| Abstract: | Abstract The effects of the acyclic analogues 3 and 4 on recognition by commonly used enzymes in recombinant DNA work have been investigated. This report shows that acyclic sugars can function in place of the normal 2′- deoxyribose moiety with some enzymes, expanding the range of possible manipulations. |
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