SYNTHESIS OF 3-ALKYL PIPERAZIN-2-ONE NUCLEOSIDES WITH POTENTIAL ANTIRETROVIRAL ACTIVITY |
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| Authors: | Abdellah Benjahad Robert Granet Pierre Krausz Claudine Bosgiraud Sylvie Delebassée |
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| Institution: | 1. Laboratoire de Chimie des Substances Naturelles , Faculté des Sciences , 123 Avenue Albert Thomas, 87060, Limoges Cedex, France;2. UFR de Pharmacie 2 rue du Docteur Marcland , 87025, Limoges Cedex, France |
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| Abstract: | Abstract Piperazinone nucleosides can be formed by N-glycosylation with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose of either piperazin-2-ones or pyrazin-2-ones followed by reduction of the heterocycle with rhodium on alumina. All the prepared compounds were tested for their activity against the Visna virus, but did not show significant antiviral activity. |
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