Synthesis of Pyrrolo[2,3-d]pyrimidines that are Structurally Related to Methylated Guanosines from tRNA and the Nucleoside Q Analogs,PreQ0 and PreQ1 |
| |
| Authors: | Chin Shu Cheng a Geoffrey C Hoops b Robert A Earl c Leroy B Townsend |
| |
| Institution: | 1. Department of Medicinal Chemistry , College of Pharmacy, University of Michigan , Ann Arbor, Michigan, 48109;2. Department of Chemistry , College of Literature, Sciences and the Arts, University of Michigan , Ann Arbor, Michigan, 48109;3. Department of Medicinal Chemistry , College of Pharmacy, University of Utah , Salt Lake City, Utah, 84112;4. Department of Chemistry , College of Literature, Sciences and the Arts, University of Michigan , Ann Arbor, Michigan, 48109;5. Department of Medicinal Chemistry , College of Pharmacy, University of Utah , Salt Lake City, Utah, 84112 |
| |
| Abstract: | Abstract The N-3- and N-2-methylated analogs of several 5-substituted 2 amino-7-(β-D-ribofuranosyl)pyrrolo2,3-d]pyrimidin-4-ones were synthesized from 5-cyano-2,4-dichloro-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrrolo2,3-d]pyrimidine (10). These compounds are analogs of nucleoside Q that are methylated in a manner similar to some of the naturally occurring methylated guanosines. |
| |
| Keywords: | Synthesis glucosidation 1 2 4-triazoles 2H-[1 2 4]triazolo[3 4-b][1 3 4]thiadiazole-3-thiones antimicrobial activity |
|
|
