Novel Tsao Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues |
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| Authors: | Rosa Alvarez Ana San-Félix Erik De Clercq Jan Balzarini María José Camarasa |
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| Affiliation: | 1. Instituto de Química Médica (C. S. I. C.) , Juan de la Cierva, 3, 28006 , Madrid , Spain;2. Rega Institute for Medical Research, Katholieke Universiteit Leuven , B-3000 , Leuven , Belgium |
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| Abstract: | Abstract Novel TSAO-T analogues, in which the ribofuranosyl moiety has been replaced by an hexofuranosyl sugar moiety, have been prepared and evaluated for their inhibitory effect on HIV-1 replication in cell culture. In contrast to the prototype compound TSAO-T, the hexofuranosyl derivatives proved not active at subtoxic concentrations. |
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