Isolation and Characterization of 3-(3-Amino-3-Carboxypropyl)Uridine from Human Urine |
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| Authors: | Girish B Chheda Henry A Tworek Arvind K Bhargava Elliot Rachlin Shib P Dutta Helen B Patrzyc |
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| Institution: | 1. Departments of Biophysics Roswell Park Memorial , Institute Buffalo , New York, 14263;2. Laboratory Medicine Roswell Park Memorial Institute , Buffalo, New York, 14263;3. Department of Medicinal Chemistry , University of Utah , Salt Lake City, Utah, 84112 |
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| Abstract: | Abstract A new modified nucleoside, 3-(3-amino-3-carboxypropyl)-uridine was isolated from a 24 hour collection of a normal human urine. The structure was assigned on the basis of UV, NMR and mass spectrometry data and confirmed by comparison of the spectral data and HPLC mobilities with those of an authentic sample. Origin and significance of this nucleoside in relation to tRNA is discussed. The new nucleoside is present also in the urine of cancer patients but in smaller amounts. |
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