Synthesis and Antiherpetic Activities of Several Acyclic Analogues Of Guanosine |
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| Authors: | Hirofumi Furusho Takahiro Ogata Akihisa Kato Yoshie Sato Tohru Endo Akira Kaji |
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| Affiliation: | 1. Research Institute for Molecular Genetics, TSUMURA &2. CO. , 3586 Yoshiwara, Ami-Machi, Inashiki-Gun, Ibaraki, 300-11, Japan;3. Department of Microbiology , School of Medicine, University of Pennsylvania , Philadelphia, PA, 19104-6076, USA |
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| Abstract: | Abstract Several acyclic analogues of guanosine, 2′-deoxy-2′, 3′-secoguanosine(3), 3′-deoxy-2′, 3′-secoguanosine (4), and 2′-, 3′-dideoxy-2′-, 3′-secoguanosine were synthesized from guanosine. In addition, the 3′-, 5′-cyclic phosphate (21) and 3′-, 5′-cyclic methylphosphonates (22a, b) of 3 were also prepared. At concentrations up to 300 μM none of these compounds had significant antiherpetic activity in antiviral assays in vitro. |
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