Novel Synthesis of a 2, 5'-O-Cycloimidazole Nucleoside |
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| Authors: | Graham Mackenzie Gordon Shaw Hilary A. Wilson |
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| Affiliation: | 1. School of Science, Humberside College of Higher Education , Hull, HU6 7RT;2. School of Chemistry, University of Bradford , Bradford, W. Yorkshire, BD7 1DP, (U.K.);3. School of Science, Humberside College of Higher Education , Hull, HU6 7RT |
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| Abstract: | Abstract A novel conversion of ethyl 5-amino-1 -(2, 3, 0-isopropylidene-β-D-ribofuranosyl)imidazole-4-carboxylate (2) to the corresponding 2, 5'-cyclo derivative (4) occurs with alkaline hypobromite or N-chlorosuccinimide and alkali. |
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| Keywords: | Antiviral nucleosides anticancer nucleosides adenosine receptor ligands |
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