Synthesis of Some Analogues Of 1-[(2-Hydroxyethoxy)-methyl]-6-(phenylthio) Thymine (HEPT) which have Different types of Acyclic Structures |
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| Authors: | Hiromichi Tanaka Tadashi Miyasaka Kouichi Sekiya Hideaki Takashima Masaru Ubasawa Issei Nitta |
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| Institution: | 1. School of Pharmaceutical Sciences , Showa University , Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan;2. Mitsubishi Kasei Corporation Research Center , Yokohama, 227, Japan |
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| Abstract: | Abstract Analogues of a recently developed specific anti-HIV-1 agent HEPT, 1-(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, having different types of acyclic moieties were synthesized based on lithiation chemistry. Anti-HIV-1 activity of these analogues is also described. |
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