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A Convenient Approach to the Synthesis of Azido-Acyclic Nucleosides |
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| Authors: | Takashi Ogawa Hiroshi Takaku Naoki Yamamoto |
| Affiliation: | 1. Laboratory of Bioorganic Chemistry, Department of Industrial Chemistry, Chiba Institute of Technology , Tsudanuma, Narashino, Chiba, 275, Japan;2. Departments of Virology and Parasitology , Yamaguchi University School of Medicine , Ube, 755, Japan |
| Abstract: | Abstract The azidation of unprotected acyclic nucleosides (4) was carried out in a one-pot reaction by means of the reagent triphenylphosphine-carbon tetraiodide-sodium azide to give the corresponding mono-azido-acyclic nucleosides (6) in good yields without by-products such as the di-azido-acyclic nucleosides. |
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