Cardiovascular Effects of Adenosine Derivatives in Conscious Normotensive Rats |
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| Authors: | M. Milavec-krizman H. Wagner A. Kralj J. P. Evenou F. Gadient |
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| Affiliation: | Preclinical Research, Sandoz Pharma Ltd. , CH, 4002, Basle |
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| Abstract: | Abstract All adenosine receptor agonists, regardless of their A1/A2 selectivity ratio, dose dependently reduced blood pressure (MAP) whereas their effects on heart rate (HR) and plasma renin activity (PRA) depended on their receptor subtype selectivity. Thus an adenosine receptor agonist with an optimal A1- and A2- receptor selectivity (no increase in HR and PRA) and which does not penetrate the brain, might be a useful antihypertensive drug. |
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