SYNTHESIS AND STRUCTURE DETERMINATION OF A NUCLEOSIDEDERIVED NEW HETEROCYCLIC SYSTEM: 8H,10H,15b(S)-2,3,6,7-TETRAHYDRO-1,5,3-DIOXAZEPINO[3,2-c]INDOLO[3,2-g]PTERIDINE-7-ONE |
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| Authors: | Ping Ge Gregory O Voronin Thomas I Kalman∗ |
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| Institution: | Department of Medicinal Chemistry , School of Pharmacy, State University of New York at Buffalo , Amherst, Ny, 14260 |
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| Abstract: | Abstract Condensation of 5-aminocytidine with N-methylisatin yielded a new heterocyclic system, 8H,10H,15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino3,2-c]indolo3,2-g]pteridine-7- one. The assignment of S configuration at position 15b, which is generated as a result of the nucleophilic attack of the 5′-hydroxy of the ribosyl moiety at the position 6 of the cytosine base, is discussed. |
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