P1-Purinergic Receptor-Mediated Modulation of TSH Actions on FRTL-5 Thyroid Cells: Possible Switching From cAMP Pathway to Inositol Phosphate-Ca System |
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| Authors: | Y Kondo K Sho M A Majid F Okajima |
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| Institution: | Department of Physical Biochemistry , Institute of Endocrinology, Gunma University , Maebashi, 371, Japan |
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| Abstract: | Abstract In thyroid cells, a PI-agonist, via G1 like protein, enhanced a TSH-induced I?-efflux by intensifying a TSH-dependent inositol polyphosphate production followed by a Ca2+ mobilization, but diminished a TSH-dependent DNA synthesis by attenuating a TSH-dependent cAMP accumulation. |
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