A Computer Generated Model of Adenosine Receptors Rationalising Binding and Selectivity of Receptor Ligands |
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| Authors: | Ronald J. Quinn Michael J Dooley Andre Escher Fiona A. Harden Hiranthi Jayasuriya |
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| Affiliation: | Division of Science and Technology , Griffith University , Brisbane, 4111, Australia |
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| Abstract: | Abstract Computer graphic analyses on a broad spectrum of adenosine receptor ligands has shown that both the A1 and A2 adenosine receptors have three binding sites. The spatial relationship of these three binding sites has been defined. Adenosine orientation at A1 and A2 is different. |
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