Synthesis and Biological Activity of Various Selenenyl and Tellurenyl-Substituted Deoxyuridines and Deoxyuridylates |
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Authors: | Ralph J. Cisneros Louis A. Silks III Jerome D. Odom R. Bruce Dunlap |
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Affiliation: | Dept. of Chemistry , University of South Carolina , Columbia, South Carolina, 29208 |
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Abstract: | Abstract 5-Methylselenenyl and 5-phenyltellurenyldeoxyuridines were constructed via the transmetallation of the corresponding 5-bromo-3′,5′-bis(dimethyl-tert-butyl)silyl deoxyuridine with n-butyllithium followed by electrophilic trapping of the anion with the appropriate reagent. These substituted deoxyuridylates have been evaluated as potenital inhibitors of Lactobacillus casei thymidylate synthase. |
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