Age-Elated Impairment of Relaxation To ATP in Rabbit Aortas |
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| Authors: | A Chinellato L Pandolfo E Ragazzi L Caparrotta G Fassina |
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| Institution: | Department of Pharmacology , University of Padua , Lgo. E.Meneghetti 2, 35131, Padova, Italy |
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| Abstract: | Abstract Effect of aging on endothelium-dependent and independent relaxation was studied in rabbit aorta. Response to Ach was similar in young and adult animals. ATP and NaN02 showed both lower potency and efficacy in adult animals. Vascular smooth muscle might be of relevance in the age-related impaired relaxation to ATP. |
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