Synthesis and Antiviral Properties of New Cycloalkanol Derivatives of Guanine |
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| Authors: | S. Halazy M. Kenny J. Dulworth A. Eggenspiller |
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| Affiliation: | 1. Marion Merrell Dow Research Institute , 16 rue d'Ankara, 67000 , Strasbourg , France;2. Marion Merrell Dow Inc. , 9550 N. Zionsville Road, Indianapolis , 46268 , USA |
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| Abstract: | Abstract New conformationaly constrained cycloalkanol derivatives of guanine have been prepared as potential anti-herpetic agents. None of these compounds was found to inhibit HSV or CMV replication in cell culture but some of them show some antagonism or synergism towards acyclovir protecting effect. |
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