Biosynthesis of the Naturally Occurring Nucleoside Antibiotics from Adenosine |
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| Authors: | Robert J Suhadolnik Jeffery C Hanvey Somchai Pornbanlualap Joseph M Wu Kamal N Tiwari Anna K Hebbler |
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| Institution: | 1. Department of Biochemistry , Temple University School of Medicine , Philadelphia, Pennsylvania, 19140;2. Department of Chemistry , University of Alabama , Tuscaloosa, AL, 35486 |
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| Abstract: | Abstract 9-β-D-Arabinofuranosyladenine (ara-A, l), first isolated from the culture filtrates of StreDtomyces antibioticus, has a broad spectrum of activity against DNA viruses in cell culture and is successfully used in therapy of herpes simplex encephalitis, neonatal herpes, herpes zoster and chronic myelogenous leukemia1. 2′-Chlorodeoxycoformycin (2′CldCF, 2), 2′-amino-Zt-deoxyadenosine (3) and nucleocidin (4) have been isolated from the culture medium of Fctinomadura and S. clavus, respectively. |
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