New Acyclic C-Nucleosides of the Imidazole |
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Authors: | J. Fuentes Mota P. Areces Bravo F. Rebolledo Vicente J. I. Fernández García-Hierro J. A. Galbis Pérez |
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Affiliation: | Department of Organic Chemistry , Faculty of Sciences University of Extremadura , Badajoz, Spain |
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Abstract: | Abstract Acid catalyzed isomerization of 1-aryl-(1,2-dideoxy-D-glycero-β-L-gluco-heptofuranose) [1,2-d]-2-imidazolines (4) yields 1-aryl-4-(D-galacto-pentitol-1-yl)imidazoles (8) which can be also obtained by reductive desulphuration of 1-aryl-2-benzylthio-4-(D-galacto-pentitol-1-yl)imidazoles (6). Compounds (4) were obtained by desulphuration with Raney nickel from 1-aryl-(1,2-dideoxy-D-glycero-β-L-gluco-heptofuranose) [1,2-d]-imidazolidine-2-thiones (1) or 1-aryl-2-benzylthio-(1,2-dideoxy-D-glycero-β-L-gluco-heptofuranose) [1,2-d]-2-imidazolines (2). |
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Keywords: | Functionalized purine nucleosides IMPDH Antiviral activity |
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