Novel Acyclonucleosides. Part 2. 2, 3-Dihydroxy-1-Methoxypropyl-and 3-Hydroxy-1-Methoxypropyl-Substituted Purines |
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| Authors: | Stuart Bailey Michael R Harnden |
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| Institution: | Beecham Pharmaceuticals, Research Division, Biosciences Research Centre , Great Burgh, Epsom, Surrey , KT18 5XQ, England |
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| Abstract: | Abstract Novel purine nucleoside analogues in which the N-9 ribosyl moiety is replaced by a 2,3-dihydroxy-1-methoxypropyl or 3-hydroxy- 1-methoxy-propyl substituent and their N-7 substituted isomers have been synthesized and tested for antiviral activity. |
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| Keywords: | Herpes simplex virus type‐1 Thymidine kinase Herpesviridae Deoxyuridine substrates IC50 values |
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