New Unnatural L-Nucleoside Enantiomers:From Their Stereospecific Synthesis to Their Biological Activities |
| |
| Authors: | G. Gosselin V. Boudou J.-F. Griffon G. Pavia C. Pierra J.-L. Imbach |
| |
| Affiliation: | Laboratoire Chimie Bioorganique, UMR CNRS 5625 , Université Montpellier II , 34095, Montpellier |
| |
| Abstract: | Abstract Several purine and pyrimidine β-L-dideoxynucleosides were stereospecifically synthesized and their antiviral properties examined. Two of them, namely β-L-2′,3′-dideoxyadenosine (β-L-ddA) and its 2′,3′-didehydro derivative (β-L-d4A) were found to have significant anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activities in cell culture. |
| |
| Keywords: | |
|
|
