Sulfurization Efficiency in the Solution Phase Synthesis of Deoxyribonucleoside Phosphorothioates - Comparison of Sulfur Triethylamine with Various Sulfurizing Agents 1 |
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| Authors: | Zacharia S Cheruvallath Douglas L Cole Vasulinga T Ravikumar |
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| Institution: | Isis Pharmaceuticals , 2292 Faraday Ave., Curlsbad, CA, 92008 |
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| Abstract: | Abstract Efficient solution-phase synthesis of nucleoside phosphorothioates utilizing phosphoramidite approach is described. Elemental sulfur in combination with triethylamine is the prefered choice for sulfurization of phosphite triester to phosphorothioates. |
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