Synthesis of Oligodeoxyribonucleoside Methylphosphonates Containing 2-Aminopurine |
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| Authors: | Yuanzhong Zhou Paul O P. Ts'o |
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| Affiliation: | Department of Biochemistry , School of Hygiene and Public Health The Johns Hopkins University , Baltimore, Maryland, 21205, USA |
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| Abstract: | Abstract Oligodeoxyribonucleoside methylphosphonates containing multiple 2-aminopurine bases were synthesized by solid-phase phosphonamidite chemistry for investigating their triple helix formation with natural DNA or other duplex targets and for cellular uptake studies of the methylphosphonate oligomers. The base-labile phenoxyacetyl group was used as the N 2-amino protecting group for 2-aminopurine, allowing the final deprotection of the oligomers to be performed under the standard ethylenediamine condition. |
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