Synthesis and NMR Spectra of Some New Carbohydrate Modified Uridine Phosphoramidites |
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Authors: | Pawel J Serafinowski Colin L Barnes |
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Institution: | CRC Centre for Cancer Therapeutics at the Institute of Cancer Research , 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK |
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Abstract: | Abstract The one step reaction of 2′- and 3′-keto derivatives of uridine with bromodifluoromethyltris(dimethylamino)]phosphonium bromide and zinc gives the corresponding 2′- and 3′-difluoromethylene nucleosides in good yield. Desilylation and phosphitylation of the resultant 2′- or 3′-hydroxyls provides the target 2′- and 3′-phosphoramidites 7 and 8 for use in oligonucleotide synthesis1. |
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