Chemical and Photochemical Ligation of Oligonucleotide Blocks |
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| Authors: | Robert L Letsinger Taifeng Wu Robert Elghanian |
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| Institution: | Department of Chemistry , Northwestern University , IL 60091, Evanston , U.S.A |
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| Abstract: | Abstract Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide containing a -OP(O)(O?)S- link can hnction as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target. |
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