Conformation of Lariat Structures Formed in the Splicing of Pre-mRNA by NMR Spectroscopy |
| |
| Authors: | A Sandström N Balgobin A Nyilas G Remaud J-M Vial X-X Zhou |
| |
| Institution: | Department of Bioorganic Chemistry , Box 581, Biomedical Center, University of Uppsala , S-75123, Uppsala, Sweden |
| |
| Abstract: | Abstract Temperature dependent 1H- and 31p-NMR studies have shown that lariat (branched) trimers show a preferential 2′ → 5′ stacking, while the branched tetramers resemble 3′ → 5′ linked linear trimers, reminiscent of a single stranded A-RNA helix. |
| |
| Keywords: | |
|
|
