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Synthesis of Suitably-Protected Phosphoramidites of 2′-Fluoro-2′-Deoxyguanosine and 2′-Amino-2′-Deoxyguanosine for Incorporation Into Oligoribonucleotides |
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| Authors: | Fritz Benseler David M Williams Fritz Eckstein |
| Institution: | 1. Max-Planck-Institut fur experimentelle Medizin , Abteilung Chemie, Hermann-Rein-Strasse 3, W-3400, Gottingen, FRG;2. Max-Planck-Institut fur experimentelle Medizin , Abteilung Chemie, Hermann-Rein-Strasse 3, W-3400, Gottingen, FRG;3. Cruachem, Todd Campus , West of Scotland Science Park, Glasgow, UK |
| Abstract: | Abstract A novel synthesis of 2′-fluoro-2′-deoxyguanosine employing DAST as the fluorinating agent is presented. The preparation of its phosphoramidite as well as that of 2′-amino-2′-deoxyguanosine is also described. |
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