Synthesis and Cytostatic Activity of Halomethylthiazole C-Nucleosides and Analogues1 |
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| Authors: | M. Teresa García-López Rosario Herranz Paloma P. Méndez-Castrillón |
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| Affiliation: | Institute de Química Médica , Juan de la Cierva 3. Madrid-6, Spain |
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| Abstract: | Abstract The synthesis of 2-(β-D-ribofuranosyl)-and 2-(tetrahydropyran-2-yl)-4-halomethylthiazoles from 2, 5-anhydro-D-allonthioamide and tetrahydropyran-2-thiocarboxamide is described. Bromination of 2-(β-D-ribofuranosyl)- and 2-tetrahydropyran-2-yl)-4-methylthiazole with NBS is studied. Cytostatic activity against HeLa cells of all the compounds is reported. |
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