Role of Adenosine Kinase in the Biological (Antiviral and Anticellular) Activities of Adenosine Analogues |
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| Authors: | Marina Cools Erik De Clercq John C. Drach |
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| Affiliation: | 1. Rega Institute for Medical Research, Katholieke Universiteit Leuven , B-3000, Leuven, Belgium;2. Department of Oral Biology , School of Dentistry, The University of Michigan , Ann Arbor, Michigan, 48109, U.S.A. |
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| Abstract: | Abstract A paired adenosine kinase-positive/adenosine kinase-negative cell system is proposed to distinguish those adenosine analogues that need to be phosphorylated to exert their biological effects from those that are mainly targeted at S-adenosyl-L-homocysteine hydrolase. |
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