Stereocontrolled Transesterification for the Synthesis of Chiral Phosphite Triester Backbone |
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| Authors: | Masatsugu Mizuguchi ? ¶ Keisuke Makino ? |
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| Institution: | 1. Department of Polymer Science and Engineering , Kyoto Institute of Technology Matsugasaki , Sakyo-ku, Kyoto , 606 , Japan;2. Rational Drug Design Laboratories , Matsukawa-machi, Fukushima , 960-12 , Japan |
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| Abstract: | Abstract We have developed stereocontrolled transesterification for the synthesis of chiral phosphite mester backbone under basic conditions. Substrate phosphite triesters with phenoxy derivative substituents as leaving groups were separated into individual stereoisomers and reacted with hydroxyl-containing compounds to form desired backbone. |
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