Efficacy of an inactivated canine coronavirus vaccine in pups |
| |
Authors: | Pratelli A Tinelli A Decaro N Cirone F Elia G Roperto S Tempesta M Buonavoglia C |
| |
Institution: | Department of Animal Health and Well-being, Faculty of Veterinary Medicine, Valenzano, Bari, Italy. |
| |
Abstract: | The efficacy of an inactivated CCoV vaccine (Duramune PC) was evaluated in four pups. Two dogs were maintained non-vaccinated. Ten days after the booster shot all the pups were challenged with a field CCoV strain administered by oro-nasal route. The vaccinated pups did not display clinical signs and shed the challenge-virus for 11.25 days, evaluated by virus isolation, and 13.5 days, evaluated by PCR assay. The two non vaccinated pups displayed mild diarrhoea at day post-challenge 4 and shed the challenge-virus for 14 and 15 days respectively, by virus isolation, and for 22 and 24 days respectively, by PCR assay. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|