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Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers |
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| Authors: | Chen Gang Xia Hongguang Cai Yu Ma Dawei Yuan Junying Yuan Chengye |
| Institution: | a State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China b Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA |
| Abstract: | A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here. |
| Keywords: | Autophagy Diphenylbutylpiperidines Synthesis SAR study Inducers |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |