Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp |
| |
| Authors: | Kura Ken'ichi Kubota Takaaki Fromont Jane Kobayashi Jun'ichi |
| |
| Institution: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
b Western Australian Museum, Locked Bag 49, Welshpool DC, WA 6986, Australia |
| |
| Abstract: | Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino)piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells. |
| |
| Keywords: | Marine sponge Amphimedon sp 3-Alkylpyridine alkaloids Pyrinodemins E and F |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
