| D-丝氨酸在神经元-胶质细胞间通讯的新进展 |
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| 作者姓名： | He WJ Ruan HZ |
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| 作者单位： | 第三军医大学基础部神经生物学教研室,重庆,400038 |
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| 摘 要： | D-丝氨酸(D-Ser)是一种重要的胶质细胞递质,也是N-甲基-D-天冬氨酸(NMDA)受体NR1亚基上"甘氨酸位点"的主要内源性配体,具有比甘氨酸更高的结合效能.D-Ser在体内主要由丝氨酸消旋酶将L-丝氨酸消旋而来,受多种因素调控,在中枢神经系统参与调节突触可塑性、感觉信息传递、神经发育及神经兴奋性毒性等生理及病理过程,并成为阿尔采末病(AD)等神经系统疾病新的治疗靶点.本文对D-Ser在中枢神经系统的产生、代谢、生理及病理作用的研究予以综述.
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| 关 键 词： | D-丝氨酸 NMDA受体 丝氨酸消旋酶 D-氨基酸氧化酶 |
Progress in the research of D-serine on neuron-glia communication |
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| He WJ,Ruan HZ.Progress in the research of D-serine on neuron-glia communication[J].Progress in Physiological Sciences,2009,40(4):303-307. |
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| Authors: | He Wen-Juan Ruan Huai-Zhen |
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| Institution: | Department of Neurobiology, College of Medicine, Third Military Medical University, Chongqing 400038, China. |
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| Abstract: | D-serine is an important gliotransmitter in CNS. As an endogenous ligand for glycine-bind site in NR1 subunit of NMDA glutamate receptors, D-serine is more potent than glycine at activating the site. It is synthesized from L-serine via racemization of serine racemase, which is regulated by many factors. D-serine participates in many physiological and pathological progresses, including synaptic plasticity, sensory information transmission, neural development and neurotoxicity, and is supposed as potential therapeutic target for the treatment of nervous system disease like Alzheimer disease. Here, we provide an overview of recent findings on the mechanisms of its synthesis, degradation, release and physiological and pathological functions in CNS. |
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