Positively charged residues are important determinants of membrane protein topology |
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Authors: | R E Dalbey |
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Institution: | Department of Chemistry, Ohio State University, Columbus 43210. |
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Abstract: | Membrane proteins are found in a variety of conformations, with each protein spanning the membrane a set number of times and adopting a particular orientation. Positively charged residues, often located near the boundaries of transmembrane segments, appear to be involved in specifying the topology of membrane proteins. |
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