Quinobene, a new potent anti-HIV agent. |
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| Authors: | E Gruszecka-Kowalik R D Haugwitz L H Zalkow |
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| Affiliation: | School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta 30332. |
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| Abstract: | A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound. The lithium and tetramethylammonium salts of Quinobene and its complexes with Cu(II), Zn(II), Mg(II) were also prepared. In vitro tests showed considerable activity of these compounds against HIV-1. |
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