Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment |
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Authors: | Pawlak K J Zhang G Wiebe J P |
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Affiliation: | Hormonal Regulatory Mechanisms Laboratory, Department of Biology, University of Western Ontario, London, Canada. |
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