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Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment
Authors:Pawlak K J  Zhang G  Wiebe J P
Institution:Hormonal Regulatory Mechanisms Laboratory, Department of Biology, University of Western Ontario, London, Canada.
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