The Association between Serum Leptin and Post Stroke Depression: Results from a Cohort Study |
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| Authors: | Yan-tao Li Ye Zhao Hua-jing Zhang Wen-li Zhao |
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| Institution: | 1. Department of Prevention and Health Care, Tianjin Nankai Hospital, Tianjin, P. R. China.; 2. Department of Clinical Research, Tianjin Nankai Hospital, Tianjin, P. R. China.; 3. Department of Pediatrics, Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin, P. R. China.; 4. Department of Neurology, Tianjin Nankai Hospital, Tianjin, P.R. China.; Institute of Psychiatry, United Kingdom, |
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| Abstract: | BackgroundDepression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcomes. Our aim was to determine whether there was a relationship between inflammatory markers (leptin) and post-stroke depression (PSD).MethodsOne hundred and ninety-one ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of leptin at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression at 3 month.ResultsForty-four patients (23.0%) were diagnosed as having major depression at 3 month. Patients with depression showed higher serum leptin levels at 3 month after stroke (32.2 IQR, 20.8–57.7] v. 9.9 IQR, 4.6–13.1]ng/ml, respectively; P = 0.000). Serum levels of leptin ≥20 ng/ml were independently associated with PSD odds ratio (OR) 20.23, 95% confidence interval (CI) 9.11–51.26, P = 0.000], after adjusting for possible confounders.ConclusionsSerum leptin levels elevated at admission were found to be associated with PSD and may provide a new proposal for the treatment of PSD. |
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