NDRG2: a Myc-repressed gene involved in cancer and cell stress |
| |
| Authors: | Yao Libo Zhang Jian Liu Xuewu |
| |
| Institution: | The Institute of Molecular Biology and the State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an 710032, China |
| |
| Abstract: | As a master switch for cell proliferation and differentiation, Myc exerts its biological functions mainly through transcrip-tional regulation of its target genes, which are involved in cells' interaction and communication with their external environment. The N-Myc downstream-regulated gene ( NDRG ) family is composed of NDRG1, NDRG2, NDRG3 and NDRG4 , which are important in cell proliferation and differentiation. This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential. |
| |
| Keywords: | N-Myc downstream-regulated gene tumor suppressor cell stress |
| 本文献已被 PubMed 等数据库收录！ |
|
