|
|||||
|
|
The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue |
|
| Authors: | Vladimir I. Potkin Dzmitry Shcharbin Andrey A. Denisov Svetlana G. Paschkevich Maria Bryszewska Sergey K. Petkevich Alexey V. Kletskov Dmitri O. Lapotko Vladimir V. Kazbanov Tatiana A. Gurinovich Vladimir A. Kulchitsky |
| Affiliation: | 1. Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus 2. Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus, Minsk, Belarus 6. Institute of Biophysics and Cell Engineering of NASB, Akademicheskaja str. 27, Minsk, 220072, Belarus 3. Institute of Physiology of National Academy of Sciences of Belarus, Minsk, Belarus 4. Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland 5. Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA |
| Abstract: | We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |