6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides |
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| Authors: | Sperlinga Emanuela Kosson Piotr Urbanczyk-Lipkowska Zofia Ronsisvalle Giuseppe Carr Daniel B Lipkowski Andrzej W |
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| Affiliation: | Department of Pharmaceutical Sciences, University of Catania, Catania 95125, Italy. |
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| Abstract: | 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand-receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of deltorphin, dermorphin, and endomorphin with D,L-6Htc prove initial prediction. |
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