Patchy fur,a Mouse Coat Mutation Associated with X–Y Nondisjunction, Maps to the Pseudoautosomal Boundary Region |
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| Authors: | Olga Korobova Priscilla W Lane Jo Perry Steve Palmer Alan Ashworth Muriel T Davisson Norman Arnheim |
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| Institution: | aMolecular Biology Program, University of Southern California, Los Angeles, California, 90089-1340;bThe Jackson Laboratory, Bar Harbor, Maine, 04609;cSection of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, London, SW3 6JB, United Kingdom |
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| Abstract: | Patchy furis a semidominant X-linked mutation in the mouse, resulting in a sparse coat. ThePafmutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizesPafto an 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing. |
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