Fine mapping of a human chromosome 6 ferritin heavy chain pseudogene: relevance to haemochromatosis |
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| Authors: | K. M. Summers K. S. Tam P. B. Bartley J. Drysdale H. Y. Zoghbi J. W. Halliday L. W. Powell |
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| Affiliation: | (1) Department of Medicine, University of Queensland and Queensland Institute for Medical Research, Brisbane, Australia;(2) Department of Biochemistry, Tufts University, Boston, Massachusetts, USA;(3) Institute for Molecular Genetics and Department of Pediatrcis, Baylor College of Medicine, Houston, Texas, USA;(4) Queensland Institute for Medical Research, Herston Road, 4029 Herston, Queensland, Australia |
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| Abstract: | Summary We have used a somatic cell hybrid regional mapping panel for the short arm of chromosome 6, linkage analysis and a population study to map in detail a previously described ferritin heavy chain pseudogene sequence on chromosome 6. Our results show that this sequence maps to the short arm of chromosome 6 centromeric to the glyoxylase locus. The ferritin pseudogene locus is thus distant from the locus for the iron storage disease haemochromatosis, confirming previous evidence that this sequence is not a candidate for the haemochromatosis gene. |
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