The role of minor groove functional groups in DNA hydration |
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Authors: | Woods Kristen Kruger Lan Tao McLaughlin Larry W Williams Loren Dean |
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Institution: | School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA. |
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Abstract: | Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 Å. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove ‘spine of hydration’ is destabilized but essentially intact. |
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